TP 53 mutation at early stage of colorectal cancer progression from two types of laterally spreading tumors
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منابع مشابه
TP53 mutation at early stage of colorectal cancer progression from two types of laterally spreading tumors
Although most sporadic colorectal cancers (CRC) are thought to develop from protruded adenomas through the adenoma-carcinoma sequence, some CRC develop through flat lesions, so-called laterally spreading tumors (LST). We previously analyzed epigenetic aberrations in LST and found that LST are clearly classified into two molecular subtypes: intermediate-methylation with KRAS mutation and low-met...
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To date, few reports focused primarily on detecting colorectal laterally spreading tumors (LSTs) have been published. The aim of this study was to determine the visibility of LSTs on computed tomographic colonography (CTC) compared with that on colonoscopy as a standard. We retrospectively reviewed and matched data on endoscopic and CTC reports in 157 patients (161 LSTs) who received a multidet...
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BACKGROUND Laterally spreading tumors (LSTs) are generally defined as lesions >10 mm in diameter, are characterized by lateral expansion along the luminal wall with a low vertical axis. In contrast to other forms of tumor, LSTs are generally considered to have a superficial growth pattern and the potential for malignancy. We focused on this morphological character of LSTs, and analyzed the gene...
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BACKGROUND AND AIMS Laterally spreading tumor (LST) is a colorectal pre-cancerous lesion. Previous studies have demonstrated distinct LST clinicopathological characteristics in different populations. This study evaluated clinicopathological characteristics of LST in a Chinese population. METHODS A total of 259 Chinese LST patients with 289 lesions were recruited for endoscopic and clinicopath...
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(LSTs) are found frequently in the colon but not in other sections of the gastrointestinal tract. These tumors are usually less invasive than protruding or depressed tumors of the same size; thus, we have much freedom in selecting treatment modalities for LSTs. However, a pitfall lurks in the technical difficulties. It is preferable to resect every single tumor in one piece if possible, since e...
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ژورنال
عنوان ژورنال: Cancer Science
سال: 2016
ISSN: 1347-9032,1349-7006
DOI: 10.1111/cas.12930